@ARTICLE{Kasperek_K._Effects_2018, author={Kasperek, K. and Bownik, A. and Knaga, S. and Szabelak, A. and Ślaska, B. and Kwiecień, M. and Jeżewska-Witkowska, G.}, volume={vol. 21}, number={No 4}, journal={Polish Journal of Veterinary Sciences}, pages={811–813}, howpublished={online}, year={2018}, publisher={Polish Academy of Sciences Committee of Veterinary Sciences}, publisher={University of Warmia and Mazury in Olsztyn}, abstract={The aim of our study was to determine the influence of L-carnitine (L-CAR) on the cellular parameters of hen erythrocytes during a 48 hour exposure to L-CAR at concentrations of 25, 50 and 100 mg/mL in nutrient-deficient medium. Cell morphology, haemolysis, caspase 3/7 activity and glucose uptake (GU) were determined. The results showed a lower percentage of apoptotic cells and decreased haemolysis of erythrocytes treated for 48 hours at all the concentrations of L-CAR. The amino acid at 50 mg/mL inhibited the activity of proapoptotic caspase 3/7; however, it increased GU. In contrast, caspase 3/7 level was increased but GU was decreased in erythrocytes treated with 100 mg/mL of L-CAR when compared to the control. It may be hypothesized that reduction of apoptotic changes in hen erythrocytes may result from increased GU.}, type={Short communication}, title={Effects of L-carnitine on morphology and cellular parameters of hen erythrocytes}, URL={http://www.journals.pan.pl/Content/109584/PDF/20.pdf}, doi={10.24425/pjvs.2018.125592}, keywords={L-carnitine, erythrocyte morphology, caspase 3/7, hemolysis, apoptosis}, }