TY - JOUR N2 - Lipogranulomas are lesions found in histopathological liver examination in humans and in various animal species, including dogs, especially those with portosystemic shunts. They consist of macrophages and other inflammatory cells, and sometimes they contain iron salts (pigment granuloma). This study aimed at determining the number of granulomas and cellular composition of lipogranulomas in dogs with the congenital extrahepatic portosystemic shunt, and to identify factors associated with their development. 44 archival liver samples from dogs with portosystemic shunt were stained using HE, Perl’s method and – in randomly-selected cases – immunohistochemically against CD56, CD20 and CD3 (DAKO). A reduction in the size of the liver was observed in all dogs during laparotomy, and the diameter of the vessel circumventing the liver was also measured (in 24 dogs). Lipogranulomas were found in 52.3% of samples; iron salts were present in 47.8% of them; 72% of cells in lipogranulomas were macrophages. In lipogranulomas both types of lymphocytes – T and B – were seen. The presence of lipogranulomas in liver samples in dogs was connected with fatty degeneration of hepatocytes and was correlated with the age of animals and with the diameter of the abnormal vessel circumventing the liver. Their formation appears to be triggered by severe ischemia and shortage of nutrient supply. L1 - http://www.journals.pan.pl/Content/103591/PDF/03.pdf L2 - http://www.journals.pan.pl/Content/103591 PY - 2018 IS - No 2 EP - 272 DO - 10.24425/119047 KW - lipogranuloma KW - pigment granuloma KW - liver KW - portosystemic shunt KW - dog A1 - Sobczak-Filipiak, M. A1 - Męcik-Kronenberg, T. A1 - Czopowicz, M. A1 - Galanty, M. A1 - Trębacz, P. A1 - Frymus, J. A1 - Badurek, I. A1 - Szarek, J. PB - Polish Academy of Sciences Committee of Veterinary Sciences PB - University of Warmia and Mazury in Olsztyn VL - vol. 21 DA - 2018.08.30 T1 - Lipogranulomas and pigment granulomas in livers of dogs with portosystemic shunt SP - 265 UR - http://www.journals.pan.pl/dlibra/publication/edition/103591 T2 - Polish Journal of Veterinary Sciences ER -