TY - JOUR N2 - The results of experimental investigations into foaming process of poly(ε-caprolactone) using supercritical CO2 are presented. The objective of the study was to explore the aspects of fabrication of biodegradable and biocompatible scaffolds that can be applied as a temporary three-dimensional extracellular matrix analog for cells to grow into a new tissue. The influence of foaming process parameters, which have been proven previously to affect significantly scaffold bioactivity, such as pressure (8-18 MPa), temperature (323-373 K) and time of saturation (1-6 h) on microstructure and mechanical properties of produced polymer porous structures is presented. The morphology and mechanical properties of considered materials were analyzed using a scanning electron microscope (SEM), x-ray microtomography (μ-CT) and a static compression test. A precise control over porosity and morphology of obtained polymer porous structures by adjusting the foaming process parameters has been proved. The obtained poly(ε-caprolactone) solid foams prepared using scCO2 have demonstrated sufficient mechanical strength to be applied as scaffolds in tissue engineering. L1 - http://www.journals.pan.pl/Content/105897/PDF/04-paper-Kosowska%20Henczka.pdf L2 - http://www.journals.pan.pl/Content/105897 PY - 2017 IS - No 4 EP - 541 DO - 10.1515/cpe-2017-0042 KW - supercritical fluids KW - supercritical foaming KW - poly(ε-caprolactone) KW - tissue engineering KW - scaffold A1 - Kosowska, Katarzyna A1 - Henczka, Marek PB - Polish Academy of Sciences Committee of Chemical and Process Engineering VL - vol. 38 DA - 2017.12.15 T1 - The influence of supercritical foaming conditions on properties of polymer scaffolds for tissue engineering SP - 535 UR - http://www.journals.pan.pl/dlibra/publication/edition/105897 T2 - Chemical and Process Engineering ER -