Less developed regions hardly break out of path dependency. These regions encounter a serious number of problems hampering the possibility to accelerate their growth. Thus, the aim of the paper is to analyse the possibility of changing development paths by less developed regions based on previous experience in recent years. Regions that managed to change the development path were characterized by a coherent regional policy, a very good preparation and education of human capital, a strong centre of the region (the metropolitan area) facilitating the development of entrepreneurship and innovation based on new industries (like service industries) and demand for manufactured goods and services. At the same time, the main city in the region must bridge the developing new path and the global world – it must provide physical and virtual accessibility for the whole region.
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