The aim of the paper is to elaborate hypotheses concerning path development of regions and breaking out of existing paths, with emphasis on less developed regions. The findings show that changing the development paths may be caused mainly by evolutionary process and shocks play rather substitutional role in this phenomenon. Also, the higher a region is exposed and aff ected by an event, the more short-term adaptation abilities it has. Findings are unambiguous when we wanted to confi rm whether path dependence leads to specialisation of the economy and whether over-specialisation dampens innovativeness since innovations in most industries are related to locations with diverse urban base. However, findings are clear about breaking out of path dependency by less developed regions. We identify examples of less developed regions that changed their development paths despite the dependence on several declining industries. This has been achieved through the appropriate policy pursued by the regional authorities, the very good preparation and education of human capital. Thus, good regional strategy, including innovation strategy could be the leading point in breaking out of path dependency for less developed regions.
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