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Determination of the embryotoxic effect of maropitant using an in ovo model

M. Uslu R. Canbar G. Akcakavak E. Yazar

Polish Journal of Veterinary Sciences | 2022 | vol. 25 | No 2 | 357-359 | DOI: 10.24425/pjvs.2022.141821

Keywords Maropitant embryotoxicity in ovo model

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Abstract

The aim of this research was to determine the embryotoxic and teratogenic effects and lethal dose (LD50) of maropitant in ovo, using fertile chicken eggs. The study was designed in two stages, CHEST-I and CHEST-II. For CHEST-I, 210 fertile eggs were divided into seven equal groups; control, saline solution and 5 different doses of maropitant (10, 5, 2.5, 1.25, 0.625 mg/kg) injected groups. For CHEST-II, 150 fertile eggs were divided into five equal groups; control, saline solution and 3 different doses of maropitant (8, 6, 4 mg/kg)-injected groups. Eggs were opened on day 21 of incubation. Maropitant did not cause teratogenicity at any dose, while higher embryonic death rates were observed at doses above 4 mg/kg. The LD50 dose of maropitant was determined as 7.24 mg/kg. In conclusion, maropitant should only be used after full consideration of risks and benefits in pregnancy.

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Bibliography

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Authors and Affiliations

M. Uslu

R. Canbar

G. Akcakavak

E. Yazar

Department of Pharmacology and Toxicology, Veterinary Medicine, Selcuk University, 42130, Selcuklu, Konya, Turkey
Department of Pharmacology and Toxicology, Veterinary Medicine, Necmettin Erbakan University, 42310, Eregli, Konya, Turkey
Department of Pathology, Faculty of Veterinary Medicine, Yozgat Bozok University, 66900, Yozgat, Turkey

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Determination of the embryotoxic effect of maropitant using an in ovo model

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