Several psychological factors are strongly related to aggressive behaviours in university students, such as educational issues and problematic digital activity, namely Smartphone and social media addiction. At the same time, little is known about the role of student burnout syndrome in predicting these mental and social problems. Moreover, although most researchers agree with the notion of sex differences in aggression, excessive digital activity , and burnout syndrome, only a few studies have examined the role of cultural differences. Thus, the present study sought to examine whether digital technology addictions mediate the relationship between student burnout and aggressive behaviours in European and Japanese university students. For this purpose, a cross-sectional, non-experimental and online study was developed with 291 participants (202 females, M = 22.66; SD = 4.35). The findings highlighted how academic burnout and phone snubbing increase, and problematic Facebook usedecrease the risk of aggressive behaviours. In addition, phone snubbing (known as phubbing) mediates the association between student burnout and aggression. Men tend to have more aggressive behaviours than women, and Japanese students were less addicted to FB and less aggressive as well as scoring higher in phubbing than European students. In conclusion, the results confirmed the importance of including cross-cultural differences in digital technology health programs in order to minimise the risk of aggressive behaviours.