For the purpose of making of a solid body of an electric guitar the acoustic- and mechanical properties of walnut- (Juglans regia L.) and ash wood (Fraxinus excelsior L.) were researched. The acoustic properties were determined in a flexural vibration response of laboratory conditioned wood elements of 430 × 186 × 42.8 mm used for making of a solid body of an electric guitar. The velocity of shearand compression ultrasonic waves was additionally determined in parallel small oriented samples of 80 × 40 × 40 mm. The research confirmed better mechanical properties of ash wood, that is, the larger modulus of elasticity and shear modules in all anatomical directions and planes. The acoustic quality of ash wood was better only in the basic vibration mode. Walnut was, on the other hand, lighter and more homogenous and had lower acoustic- and mechanical anisotropy. Additionally, reduced damping of walnut at higher vibration modes is assumed to have a positive impact on the vibration response of future modelled and built solid bodies of electric guitars. When choosing walnut wood, better energy transfer is expected at a similar string playing frequency and a structure resonance of the electric guitar.
From the regulatory point of view a strong link between an animal model and human pharmacodynamics of biological drugs is very important to qualify the model as “relevant”. Consistent changes in cell population between human physiology and animal model gain value of this model which then can be pharmacodynamically “relevant” from the regulatory point of view. Consequently, the aim of this study was to determine how similar to human observations is the effect of selected biological drugs on blood cells in a pig model. The study was to carry out a comparative analysis of the variability of selected biochemical and hematological parameters of the blood after administration of five different human therapeutic monoclonal antibodies (mAbs) after a single subcutaneous (SC) dose in breeding pigs. The tested drugs were siltuximab (Syl- vant®), omalizumab (Xolair®), infliximab (Inflectra®), pembrolizumab (Keytruda®), and vedoli- zumab (Entyvio®) given in a single 1 mg/kg SC injection. Each of the tested drugs exerted a sig- nificant effect on at least two of the tested parameters three weeks after the administration. Siltuximab significantly influenced 9 of the analyzed parameters. Vedolizumab significantly influenced 8 of the analyzed parameters. Infliximab had the lowest impact of all the tested drugs, as it significantly influenced only two of the analyzed parameters. The study has proved that the impact of mAbs on the analyzed parameters can be significantly extended over time. This requires the monitoring of hematological parameters in the pig model even many weeks af- ter administration of a drug in a relatively small dose.