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Number of results: 5
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Abstract

The paper presents a description of the phenomena occurring on the surface of the forging dies. A detailed analysis was made of 24 pre-forging dies due to the most intensive wear in this operation. To compare the results, new tools were also analysed. The research described in the study showed that the most dangerous factor for the hot forging process analysed is thermal-mechanical fatigue, which causes small cracks, which in turn quickly leads to the formation of a crack network on the entire contact surface of the tool with forged material. The second phenomenon is the tempering of the surface of the material for a long-term temperature effect. The presence of hard iron oxides in the form of scale from forging material is the accompanying phenomenon that intensifies the processes of tool wear. The paper presents the results of the analysis of the presence of residual magnetic field for forging tools and the results of laboratory tests of wear processes of tool steels for hot work in the presence of a magnetic field and in the presence of scale.

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Authors and Affiliations

M. Zwierzchowski
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Abstract

Simulation of wave propagation in the three-dimensional (3D) modeling of the vocal tract has shown significant promise for enhancing the accuracy of speech production. Recent 3D waveguide models of the vocal tract have been designed for better accuracy but require a lot of computational tasks. A high computational cost in these models leads to novel work in reducing the computational cost while retaining accuracy and performance. In the current work, we divide the geometry of the vocal tract into four equal symmetric parts with the introduction of two axial perpendicular planes, and the simulation is performed on only one part. A novel strategy is defined to implement symmetric conditions in the mesh. The complete standard 3D digital waveguide model is assumed as a benchmark model. The proposed model is compared with the benchmark model in terms of formant frequencies and efficiency. For the demonstration, the vowels /O/, /i/, /E/, /A/, and /u/ have been selected for the simulations. According to the results, the benchmark and current models are nearly identical in terms of frequency profiles and formant frequencies. Still the current model is three times more effective than the benchmark model.
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Authors and Affiliations

Tahir Mushtaq
1
Ahmad Kamran
1
Muhammad Zubair Akbar Qureshi
2
Zafar Iqbal
3

  1. Department of Mathematics, COMSATS University Islamabad, Vehari Campus, Vehari, Pakistan
  2. Department of Mathematics, Air University, Islamabad, Pakistan
  3. Department of Mathematics, Government Graduate College of Science, Multan, Pakistan
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Abstract

AISI 316L steel was subjected to nitrocarburizing under glow discharge conditions, which was followed by DLC (diamond-like carbon) coatings deposition using the same device. The coatings were applied under conditions of direct current and pulsed glow discharge. In order to determine the influence of the produced nitrocarbon austenite layer and the type of discharge on the microstructure and mechanical properties of the coatings, the following features were analysed: surface roughness, coating thickness, structure, chemical composition, adhesion and resistance to frictional wear. For comparison purposes, DLC coatings were also deposited on steel without a nitrocarburised layer. The obtained results indicate a significant influence of the type of glow discharge on the roughness, hardness, nitrogen content and of the nitrocarburised layer on the resistance to wear by friction and adhesion of the produced coatings.
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Authors and Affiliations

T. Borowski
1
ORCID: ORCID
K. Kulikowski
1
ORCID: ORCID
M. Spychalski
1
ORCID: ORCID
K. Rożniatowski
1
ORCID: ORCID
B. Rajchel
2
B. Adamczyk-Cieślak
1
ORCID: ORCID
T. Wierzchoń
1
ORCID: ORCID

  1. Warsaw University of Technology, Faculty of Materials Science and Engineering, 141 Wołoska Str., 02-507 Warszawa, Poland
  2. Polish Academy of Sciences, Institute of Nuclear Physics, Poland
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Abstract

In this study plasma concentrations of IL-1α and IL-8 in 29 female dogs with malignant mammary gland tumours (19 without metastasis and 10 with metastasis) and in 10 healthy control animals were determined. Concentrations of IL-1α and IL-8 were analysed using a specific canine ELISA assay. Mean plasma concentrations of IL-1α and IL-8 were significantly higher (p<0.05) in female dogs with both non-metastatic and metastatic malignant tumours compared to the healthy animals. The concentrations of both tested cytokines were significantly increased (p<0.05) in the dogs with metastasis. In female dogs with mammary carcinomas, the plasma concentration of IL-1α was significantly higher (p<0.05) in the animals with grade 3 tumours compared to the dogs with grade 1 tumours. The concentration of IL-8 was significantly higher (p<0.05) in the dogs with grade 3 tumours compared to that found in the animals with grade 1 and grade 2 tumours. A moderate correlation (r=0.433) was found between IL-1α and IL-8 concentrations in the female dogs. These findings suggest that increased malignancy and invasiveness of canine mammary tumours is associated with an increased production of IL-1α and IL-8 in the tumour microenvironment, which, in turn, leads to an increase in their circulating levels. This may indicate that circulating levels of the cytokines investigated could be considered as diagnostic and prognostic markers in canine malignant mammary tumours. However, further studies in this fields are needed.
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Bibliography


Abdelmegeed SM, Mohammed S (2018) Canine mammary tumors as a model for human disease. Oncol Lett 15: 8195-8205.
Andaluz A, Yeste M, Rodriguez-Gil JE, Rigau T, Garcia F, Rivera del Alamo MM ( 2016) Pro-inflammatory cytokines: Useful markers for the diagnosis of canine mammary tumours? Vet J 210: 92-94.
Baba OK, Sood NK, Gupta K (2019) Clinical evaluation of glycoproteins and inflammatory cytokines in the serum of dogs affected with canine mammary cancer. Proc Natl Acad Sci India Sect B Biol Sci 89: 1465-1469.
Baker KJ, Houston A, Brint E (2019) IL-1 family members in cancer; two sides to every story. Front Immunol 10: 1197.
Benoy IH, Salgado R, Van Dam P, Geboers K, Van Marck E, Scharpe S, Vermeulen PB, Dirix LY (2004) Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival. Clin Cancer Res 10: 7157-7162.
Chavey C, Bibeau F, Gourgou-Bourgade S, Burlinchon S, Boissiere F, Laune D, Roques S, Lazennec G (2007) Oestrogen receptor negative breast cancers exhibit high cytokine content. Breast Cancer Res 9: R15.
Chen Y, Shi M, Yu GZ, Qin XR, Jin G, Chen P, Zhu MH (2012) Interleukin-8, a promising predictor for prog nosis of pancreatic cancer. World J Gastroenterol 18: 1123-1129.
Chiu JW, Hanafi ZB, Chew LC, Mei Y, Liu H (2021) IL-1α processing, signaling and its role in cancer progression. Cells 10: 92.
De Andres PJ, Illera JC, Caceres S, Diez L, Perez -Alenza MD, Pena L (2013) Increased levels of inter leukins 8 and 10 as findings of canine inflammatory mammary cancer. Vet Immunol Immunopathol 152: 245-251.
Derin D, Soydinc HO, Guney N, Tas F, Camlica H, Duranyildiz D, Yasasever V, Topuz E (2007) Serum IL-8 and IL-12 levels in breast cancer. Med Oncol 24: 163-168.
Elston CW, Ellis IO (1998) Assessment of histological grade. In: Systemic Pathology. Churchill Livingstone, London, pp 356-384.
Estrela-Lima A, Araujo MS, Soares RP, Ribeiro LG, Damasceno KA, Costa AT, Teixeira-Carvalho A, Martins-Filho OA, Cassali GD (2016) Plasma biomarkers profile of female dogs with mammary carcinoma and its association with clinical and pathological features. Vet Comp On-col 14: 88-100.
Fasoulakis Z, Kolios G, Papamanolis V, Kontomanolis EN (2018) Interleukins associated with breast cancer. Cureus 10: e3549.
Fernandes JV, Cobucci RN, Jatoba CA, Fernandes TA, de Azevedo JW, de Araujo JM (2015) The role of the mediators of inflammation in cancer development. Pathol Oncol Res 21: 527-534.
Gelaleti GB, Jardim BV, Leonel C, Moschetta MG, Zuccari DA (2012) Interleukin-8 as a prognostic serum marker in canine mammary gland neoplasias. Vet Immunol Immunopathol 146: 106-112.
Ginestier C, Liu S, Diebel ME, Korkaya H, Luo M, Brown M, Wicinski J, Cabaud O, Charafe-Jauffret E, Birnbaum D, Guan JL, Dontu G, Wicha MS (2010) CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Invest 120: 485-497.
Goldschmidt M, Pena L, Rasotto R, Zappulli V (2011) Classification and grading of canine mammary tumors. Vet Pathol 48: 117-131.
Haas M, Kaup FJ, Neumann S (2015) Evaluation of serum interleukin-8 (CXCL8) concentrations in tumor bearing dogs. Am J Anim Vet Sci 10: 202-211.
Holen I, Lefley DV, Francis SE, Rennicks S, Bradbury S, Coleman RE, Ottewell P (2016) IL-1 drives breast cancer growth and bone metas-tasis in vivo. Oncotarget 7: 75571-75584.
Irac SE, Oksa A, Jackson K, Herndon A, Allavena R, Palmieri C (2019) Cytokine expression in canine lym phoma, osteosarcoma, mammary gland tumour and melanoma: comparative aspects. Vet Sci 6: 37.
Kim JH, Yu CH, Yhee JY, Im KS, Sur JH (2010) Lymphocyte infiltration, expression of interleukin (IL)-1, IL-6 and expression of mutated breast cancer susceptibility gene-1 correlate with malignancy of canine mammary tumours. J Comp Pathol 142: 177-186.
Kuan EL, Ziegler SF (2018) A tumor-myeloid cell axis, mediated via the cytokines IL-1α and TSLP, promotes the progression of breast can-cer. Nat Immunol 19: 366-374.
Kumar S, Kishimoto H, Chua HL, Badve S, Miller KD, Bigsby RM, Nakshatri H (2003) Interleukin-1α promotes tumour growth and ca-chexia in MCF-7 xenograft model of breast cancer. Am J Pathol 163: 2531-2541.
Li A, Varney ML, Valasek J, Godfrey M, Dave BJ, Singh RK (2005) Autocrine role of interleukin-8 in induction of endothelial cell proliferation, survival, migration and MMP-2 production and angiogenesis. Angiogenesis 8: 63-71.
Li L, Chen L, Zhang W, Liao Y, Chen J, Shi Y, Luo S (2017) Serum cytokine profile in patients with breast cancer. Cytokine 89: 173-178.
Lyon DE, McCain NL, Walter J, Schubert C (2008) Cytokine comparisons between women with breast cancer and women with a negative breast biopsy. Nurs Res 57: 51-58.
Machado VS, Crivellenti LZ, Bottari NB, Tonin AA, Pelinson LP, Borin-Crivellenti S, Santana AE, Torbitz VD, Moresco RN, Duarte T, Duarte MM, Schetinger MR, Morsch VM, Jaques JA, Tinucci-Costa M, Da Silva AS (2015) Oxidative stress and inflammatory response biomarkers in dogs with mammary carcinoma. Pathol Res Pract 211: 677-681.
Malik A, Kanneganti TD (2018) Function and regulation of IL-1α in inflammatory diseases and cancer. Immunol Rev 281: 124-137.
Maund SL, Barclay WW, Hover LD, Axanova LS, Sui G, Hipp JD, Fleet JC, Thorburn A, Cramer SD (2011) Interleukin-1α mediates the antiproliferative effects of 1,25-dihydroxyvitamin D3 in prostate progenitor/stem cells. Cancer Res 71: 5276-5286.
Maund SL, Shi L, Cramer SD (2013) A role for interleukin-1 alpha in the 1,25 dihydroxyvitamin D3 response in mammary epithelial cells. PLoS One 8: e81367.
Mohamed MM (2012) Monocytes conditioned media stimulate fibronectin expression and spreading of inflammatory breast cancer cells in three-dimensional culture: A mechanism mediated by IL-8 signaling pathway. Cell Commun Signal 10: 3.
Monkong N, Thitiyanaporn C, Niyatiwatchanchai N, Jaroensong T (2020) Investigation of serum interleukin-8 level and clinicopathological parameters in canine mammary gland tumors. Vet Integr Sci 18: 173-182.
Pena L, De Andres PJ, Clemente M, Cuesta P, Perez-Alenza MD (2013) Prognostic value of histological grading in noninflammatory canine mammary carcinomas in a prospective study with two-year follow-up: relationship with clinical and histological characteristics. Vet Pathol 50: 94-105.
Raman D, Baugher PJ, Thu YM, Richmond A (2007) Role of chemokines in tumor growth. Cancer Lett 256: 137-165.
Salas Y, Marquez A, Diaz D, Romero L (2015) Epidemiolo gical study of mammary tumors in female dogs diagnosed during the period 2002-2012. A growing animal health problem. PLoS One 10: e0127381.
Salvatore V, Teti G, Focaroli S, Mazzotti MC, Mazzotti A, Falconi M (2017) The tumor microenvironment promotes cancer progression and cell migration. Oncotarget 8: 9608-9616.
Salven P, Hattori K, Heissig B, Rafii S (2002) Interleukin-1 alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflam-matory cell VEGF synthesis and secretion. FASEB J 16: 1471-1473.
Simeone AM, Nieves-Alicea R, McMurtry VC, Colella S, Krahe R, Tari AM (2007) Cyclooxygenase-2 uses the protein kinase C/interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells. Int J Oncol 30: 785-792.
Singer CF, Hudelist G, Gschwantler-Kaulich D, Fink -Retter A, Mueller R, Walter I, Czerwenka K, Kubista E (2006) Interleukin-1 alpha protein secretion in breast cancer is associated with poor differentiation and estrogen receptor alpha negativity. Int J Gynecol Cancer 16 (Suppl 2): 556-559.
Sleeckx N, de Rooster H, Veldhuis Kroeze EJ, Van Ginneken C, Van Brantegem L (2011) Canine mammary tumours, an overview. Reprod Domest Anim 46: 1112-1131.
Tjomsland V, Spangeus A, Vӓlilӓ J, Sandstrӧm P, Borch K, Druid H, Falkmer S, Falkmer U, Messmer D, Larsson M (2011) Interleukin 1α sustains the expression of inflammatory factors in human pancreatic cancer microenvironment by targeting cancer-associated fibroblasts. Neo-plasia 13: 664-675.
Todorović-Raković N, Milovanović J (2013) Interleukin-8 in breast cancer progression. J Interferon Cytokine Res 33: 563-570.
Yokoe T, Iino Y, Takei H, Horiguchi J, Koibuchi Y, Maemura M, Ohwada S, Morishita Y (1997) Changes of cytokines and thyroid function in patients with recurrent breast cancer. Anticancer Res 17: 695-699.
Yuan A, Chen JJ, Yao PL, Yang PC (2005) The role of interleukin-8 in cancer cells and microenvironment interaction. Front Biosci 10: 853-865.
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Authors and Affiliations

M. Szczubiał
1
W. Łopuszyński
2
R. Dąbrowski
1
M. Bochniarz
1
P. Brodzki
1

  1. Department and Clinic of Animal Reproduction, Faculty of Veterinary Medicine, University of Life Sciences, Gleboka 30, 20-612 Lublin, Poland
  2. Department of Pathomorphology and Forensic Veterinary Medicine, Faculty of Veterinary Medicine, University of Life Sciences, Gleboka 30, 20-612 Lublin, Poland
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Abstract

In the present investigation optical, electro-optical and dielectric properties have been measured for nematic liquid crystal (NLC) material 1550C which consists of 4’-(trans, trans-4-alkylbicyclohexyl) carbonates and 4’-(4-(trans,trans-4-alkyl)-4-cyanobicyclohexane, dispersed with fluorescent dye (Benzo 2,1,3 Thiadiazole) in two different concentrations. Photoluminescence has been enhanced for a dye dispersed system which is the key finding of this investigation. UV absorbance study has also been performed and found to be increased for composite system. Enhanced birefringence after dispersion of dye into pure NLC is also a prominent result of this investigation. Relative permittivity, threshold voltage and dielectric anisotropy have also been measured and found to be increased. The outcome of the present work may be very useful in the construction of liquid crystal displays (LCDs).

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Authors and Affiliations

G. Pathak
K. Agrahari
A. Roy
A. Srivastava
O. Strzezysz
K. Garbat
R. Manohar

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