The subject matter of this article constitutes the semiotic mapping of human of knowledge which results from cognition. Departing from the presentation of human subjects as world-model-builders, it places epistemology among the sciences of science and the sciences of man. As such the understanding of epistemology is referred either to a static state of knowledge or to a dynamic acquisition of knowledge by cognizing subjects. The point of arrival, in the conclusive part of a this article, constitutes the substantiation of the two understandings of epistemology, specified, firstly, as a set of investigative perspectives, which the subject of science has at his/her disposal as a knower on the metascientific level, or, secondly, as a psychophysiological endowment of a cognizing subject who possesses the ability of learning and/or knowing a certain kind of information about cognized reality.