This paper presents the results of research regarding measurements of the values of pressure drops during horizontal flow of gas-liquid and gas-liquid-liquid mixture through 180o pipe bends. The conducted insightful analysis and assessment during multi-phase flow in pipe bends has enabled to develop a new method for determination of their values. This new method for determining pressure drops ensures higher precision of calculation in comparison to other methods presented in literature and can be applied for calculation of these parameters during multi-phase flows in pipe bends with various geometries.