Vaccination is a common routine for prevention and control of human and animal diseases by inducing antibody responses and cell-mediated immunity in the body. Through vaccinations, smallpox and some other diseases have been eradicated in the past few years. The use of a patho- gen itself or a subunit domain of a protein antigen as immunogens lays the basis for traditional vaccine development. But there are more and more newly emerged pathogens which have expe- rienced antigenic drift or shift under antibody selective pressures, rendering vaccine-induced im- munity ineffective. In addition, vaccine development has been hampered due to problems includ- ing difficulties in isolation and culture of certain pathogens and the antibody-dependent enhancement of viral infection (ADE). How to induce strong antibody responses, especially neu- tralizing antibody responses, and robust cell-mediated immune responses is tricky. Here we re- view the progress in vaccine development from traditional vaccine design to reverse vaccinology and structural vaccinology and present with some helpful perspectives on developing novel vac- cines.
Natural gas is a mixture of 21 components and it is widely used in industries and homes. Knowledge of its thermodynamic properties is essential for designing appropriate processes and equipment. This paper presents simple but precise correlations of how to compute important thermodynamic properties of natural gas. As measuring natural gas composition is costly and may not be effective for real time process, the correlations are developed based on measurable real time properties. The real time properties are temperature, pressure and specific gravity of the natural gas. Calculations with these correlations are compared with measured values. The validations show that the average absolute percent deviation (AAPD) for compressibility factor calculations is 0.674%, for density is 2.55%, for Joule-Thomson coefficient is 4.16%. Furthermore, in this work, new correlations are presented for computing thermal properties of natural gas such as enthalpy, internal energy and entropy. Due to the lack of experimental data for these properties, the validation is done for pure methane. The validation shows that AAPD is 1.31%, 1.56% and 0.4% for enthalpy, internal energy and entropy respectively. The comparisons show that the correlations could predict natural gas properties with an error that is acceptable for most engineering applications.
The aim of the article is to analyze literary images of women who had an impact on the history of Poland in the historical novel Gambit hetmański (2014), written by Robert Foryś. This type of fiction is a popular variety of the genre, its main theme is the conflict between political factions fighting for power. The leaders of the factions are women. The article focus on the answer to the question: whether Foryś creating scandalous portraits of women who reach for power is a threat or a chance for them to recall and preserve their presence in history.
The aim of the following paper is to compare the female protagonists of Honoré de Balzac’s novel that dates back to 1842. The comparison is drawn in the context of two philosophical notions which are in opposition: volonté, understood as intent and desire to achieve goals or realize passions, and liberum arbitrium representing the free will to make conscious personal decisions. Mrs de l’Estorade, alias Renée de Maucombe, is the most conspicuous example of a character, who seems to be driven by social determinism. However, this assumption is paradoxically far from truth because the actions she takes reflect the principles of liberum arbitrium. The epistolary form of the novel complements the analysis of the aforementioned concepts. It allows the women to give vent to their feelings and explain the reasons behind their choices.
This work describes a new study to achieve a combination of modified function projective synchronization between three different chaotic systems through adaptive control. Using the Lyapunov function theory, the asymptotic stability of the error dynamics is obtained and discussed. Further, we set some appropriate initial conditions for the state variables and assigning specific values to the parameters and obtain the graphical results, which shows the efficiencies of the new method. Finally, we summarized our work with conclusion and references.
The article corresponds to the 400th death annniversary of two famous European writers – Cervantes and Shakespeare – celebrated all around the world. The author tells about their lifes and takes into consideration the possiblility of their meeting together in Vailladolid. Besides, the author emphasizes on the qualities that are in common for Shakespeare’s and Cervantes’ works – among others the universality (their readers were both educated as well as simple), the ability to create symbolic figures and the application of colloquial language.
In her reflections on cultural memory, which “is based on communication through media,” Astrid Erll uses the term “remediation” in order to “refer to the fact that memorable events are usually represented again and again, over decades and centuries, in different media: in newspaper articles, photography, diaries, historiography, novels, films, etc.” Some of these events may even become sites of memory. In my article, in relation to cultural memory studies, I contemplate the genocide of the Yezidis in the Sinǧār district, which was committed by ISIS militants in August 2014 and in the following months, as reflected in four Iraqi novels written in the Arabic language. They are: Raqṣat al-ǧadīla wa-an-nahr (“The Dance of the Braid and the River”, 2015) by Wafā’ ‘Abd ar-Razzāq, ‘Aḏrā’ Sinǧār (“Sinǧār’s Virgin”, 2016) by Wārid Badr as-Sālim, Šamdīn (“Šamdīn”, 2016) by Rāsim Qāsim, and Šaẓāyā Fayrūz (“The Shattered Fragments of Fayrūz”, 2017) by Nawzat Šamdīn. By analysing the ways in which these writers depict ISIS persecution of the Yezidis, I aim to answer, among others, the following questions: What are their reasons for a literary documentation of these events? Is the iconic image of the genocide which emerges in the four novels similar to that outlined in the West media coverage? Therefore, the first part of the article concentrates on attitudes of the above-mentioned Iraqi writers to the Sinǧār tragedy. In the second part, the plots of their novels are briefly described with the focus on how the reality intermingles with fiction. In the third and in the fourth parts, literary modes of expression, which serve to create a symbolic resistance of Yezidi victims against their oppressors, by giving them voice and showing alternative realities and fantastic events, are examined.
The aim of the article is to present the issue of loneliness of Iraqi women on the basis of selected novels written by Iraqi female writers in the 21st century. The first part of the article, which is preceded by an introduction to the topic, includes general information about the development of novels by Iraqi women writers since the second half of the 1990s and some remarks about their methods of portraying female characters. The second part of the article provides examples of lonely women in their narratives whereas the third part depicts a story of Riyām, the heroine in the novel Riyām wa-Kafā (Riyam and Kafa, 2014) by Hadiya Husayn, in a more detailed way.