References:

Abdelnour SA, Hassan MA, El‐Ratel IT, Essawi WM, El‐Raghi AA, Lu Y, Sheiha AM (2022) Effect of addition of L‐carnitine to cryopres-ervation extender on rabbit post‐thaw semen parameters, antioxidant capacity, mitochondrial function, apoptosis, and ultrastructure changes. Reprod Domest Anim 57: 902-911.
Ahmadi A, Shadboorestan A, Nabavi S, Setzer W, Nabavi S (2015) The role of hesperidin in cell signal transduction pathway for the preven-tion or treatment of cancer. Curr Med Chem 22: 3462-3471.
AL‐Megrin WA, Alomar S, Alkhuriji AF, Metwally DM, Mohamed SK, Kassab RB, Abdel Moneim AE, El‐Khadragy MF (2020) Luteolin protects against testicular injury induced by lead acetate by activating the Nrf2/HO‐1 pathway. IUBMB Life 72: 1787-1798.
Alvarez JG, Holland MK, Storey BT (1984) Spontaneous Lipid Peroxidation in Rabbit Spermatozoa: A Useful Model for the Reaction of O2 Metabolites with Single Cells. Oxygen Transport to Tissue-V: 169: 433-443.
Bansal AK, Bilaspuri G (2011) Impacts of oxidative stress and antioxidants on semen functions. Vet Med Int 2011: 686137
Bucak MN, Ateşşahin A, Varışlı Ö, Yüce A, Tekin N, Akçay A (2007) The influence of trehalose, taurine, cysteamine and hyaluronan on ram semen: microscopic and oxidative stress parameters after freeze–thawing process. Theriogenology 67: 1060-1067.
Castellini C, Dal Bosco A, Ruggeri S, Collodel G (2011) What is the best frame rate for evaluation of sperm motility in different species by computer-assisted sperm analysis? Fertil Steril 96: 24-27.
Chatterjee S, Gagnon C (2001) Production of reactive oxygen species by spermatozoa undergoing cooling, freezing, and thawing. Mol Reprod Dev 59: 451-458.
Chaveiro A, Santos P, Da Silva F (2007) Assessment of sperm apoptosis in cryopreserved bull semen after swim‐up treatment: a flow cy-tometric study. Reprod Domest Anim 42: 17-21.
Chen B, Lan Z, Sun WQ, Cui Q, Si W (2022) Cryopreservation did not affect sperm DNA methylation levels of genes related to fertilization and embryonic development of cynomolgus macaque (Macaca fascicularis). Cryobiology 108: 51-56.
Chen Q, Liu S, Chen J, Zhang Q, Lin S, Chen Z, Jiang J (2012) Luteolin induces mitochondria-dependent apoptosis in human lung adenocar-cinoma cell. Nat Prod Commun 7: 29-32.
Chen Z, Kong S, Song F, Li L, Jiang H (2012) Pharmacokinetic study of luteolin, apigenin, chrysoeriol and diosmetin after oral administration of Flos Chrysanthemi extract in rats. Fitoterapia 83: 1616-1622.
Choi YJ, Kang JS, Park JH, Lee YJ, Choi JS, Kang YH (2003) Polyphenolic flavonoids differ in their antiapoptotic efficacy in hydrogen peroxide–treated human vascular endothelial cells. J Nutr 133: 985-991.
Curry M, Redding B, Watson P (1995) Determination of water permeability coefficient and its activation energy for rabbit spermatozoa. Cryo-biology 32: 175-181.
De Lamirande E, Gagnon C (1995) Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects. Hum Reprod 10: 15-21.
Ding S, Hu A, Hu Y, Ma J, Weng P, Dai J (2014) Anti-hepatoma cells function of luteolin through inducing apoptosis and cell cycle arrest. Tumor Biol 35: 3053-3060.
Domingo P, Olaciregui M, González N, De Blas I, Gil L (2018) Long-term preservation of freeze-dried rabbit sperm by adding rosmarinic acid and different chelating agents. Cryobiology 81: 174-177.
Fadl AM, El-Shahat KH, Abdelnaby EA (2022) Influence of alpha linolenic acid on the motility, viability, antioxidant activity and fertility of frozen-thawed New Zealand white rabbit buck semen. World Rabbit Sci 30: 219-226.
Fulda S, Gorman AM, Hori O, Samali A (2010) Cellular stress responses: cell survival and cell death. Int J Cell Bio 2010: 214074.
GJ Alekhya Sita, Gowthami M, Srikanth G, Krishna MM, Sajjarao M, Nagarjuna K, Nagarjuna M, Chinnaboina G, Mishra A, SreeHarsha N (2019) Protective role of luteolin against bisphenol A-induced renal toxicity through suppressing oxidative stress, inflammation, and upregu-lating Nrf2/ARE/HO-1 pathway. IUBMB Life 71: 1041-1047.
Ijaz MU, Ayaz F, Mustafa S, Ashraf A, Albeshr MF, Riaz MN, Mahboob S (2022) Toxic effect of polyethylene microplastic on testicles and ameliorative effect of luteolin in adult rats: Environmental challenge. J King Saud Univ Sci 34: 102064.
İnanç ME, Güngör Ş, Avdatek F, Yeni D, Gülhan MF, Olğaç KT, Denk B, Taşdemir U (2022) Thymoquinone improves motility, plasma membrane integrity and DNA integrity of frozen-thawed ram semen. Andrologia 54: e14547.
Jiménez-Rabadán P, García-Álvarez O, Vidal A, Maroto-Morales A, Iniesta-Cuerda M, Ramón, M, del Olmo E, Fernández-Santos R, Garde JJ, Soler AJ (2015) Effects of vitrification on ram spermatozoa using free-egg yolk extenders. Cryobiology 71: 85-90.
Kim CY, Yu QM, Kong HJ, Lee JY, Yang KM, Seo JS (2020) Antioxidant and anti-inflammatory activities of Agrimonia pilosa Ledeb. extract. Evid Based Complement Altern Med 2020: 8571207.
Kim HH, Funaro M, Mazel S, Goldstein M, Schlegel PN, Paduch DA (2013) Flow cytometric characterization of apoptosis and chromatin damage in spermatozoa. Reprod Biomed Online 26: 393-395.
Kim S, Lee YJ, Kim YJ (2011) Changes in sperm membrane and ROS following cryopreservation of liquid boar semen stored at 15oC. Anim Reprod Sci 124: 118-124.
Kocic B, Kitic D, Brankovic S (2013) Dietary flavonoid intake and colorectal cancer risk: evidence from human population studies. J BUON 18: 34-43.
Küçük N, Raza S, Matsumura K, Uçan U, Serin İ, Ceylan A, Aksoy M (2021) Effect of different carboxylated poly l-lysine and dimethyl sulfoxide combinations on post thaw rabbit sperm functionality and fertility. Cryobiology 102: 127-132.
Lim SH, Jung SK, Byun S, Lee EJ, Hwang JA, Seo SG, Kim YA, Yu JG, Lee KW, Lee H J (2013) Luteolin suppresses UVB‐induced pho-toageing by targeting JNK1 and p90RSK2. J Cell Mol Med 17: 672-680.
Luo S, Li H, Mo Z, Lei J, Zhu L, Huang Y, Fu R, Li C, Huang Y, Liu K, Chen W, Zhang L (2019) Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K/Akt signaling pathway. Exp Mol Med 51: 1-11.
Martin G, Sabido O, Durand P, Levy R (2004) Cryopreservation induces an apoptosis-like mechanism in bull sperm. Biol Reprod 71: 28-37.
Mocé E, Vicente JS (2009) Rabbit sperm cryopreservation: a review. Anim Reprod Sci 110: 1-24.
Mohammed AK, Khalil WA, Youssef H F, Saadeldin IM, Gabr SA, Hammad ME, Mehrez AZ (2021) Influence of adding zeolite loaded with different charges to semen extender on sperm quality in rabbits after cryopreservation. Cryobiology 103: 107-115.
Mohammed KM, Darwish GM, Rawash ZM, Taha AM (2022) Cryopreservation of rabbit semen: impacts of permeable and non-permeable mixture of cryoprotectant, male group individuality, freezing rate, semen package size and antioxidant bovine serum albumin on rabbit semen freezability. World Rabbit Sci 30: 227-238.
Owumi SE, Ijadele AO, Arunsi UO, Odunola OA (2020) Luteolin abates reproductive toxicity mediated by the oxido-inflammatory response in Doxorubicin-treated rats. Toxicol Res App 4: 1-16.
Paál D, Strejček F, Tvrdá E, Vašíček J, Baláži A, Chrenek P, Massányi P (2017) Taurine does not improve the quality of short‐term stored rabbit spermatozoa in vitro. Reprod Domest Anim 52: 1046-1051.
Peña FJ, Johannisson A, Wallgren M, Rodrı́guez-Martı́nez H (2003) Assessment of fresh and frozen–thawed boar semen using an Annex-in-V assay: a new method of evaluating sperm membrane integrity. Theriogenology 60: 677-689.
Petruska P, Capcarova M, Sutovsky P (2014) Antioxidant supplementation and purification of semen for improved artificial insemination in livestock species. Turk J Vet Anim Sci 38: 643-652.
Rosato MP, Iaffaldano N (2013) Cryopreservation of rabbit semen: comparing the effects of different cryoprotectants, cryoprotectant-free vitrification, and the use of albumin plus osmoprotectants on sperm survival and fertility after standard vapor freezing and vitrification. Theri-ogenology 79: 508-516.
Salisbury GW, VanDemark NL, Lodge JR (1978) Physiology of reproduction and artificial insemination of cattle.
Sarıözkan S, Türk G, Cantürk F, Yay A, Eken A, Akçay A (2013) The effect of bovine serum albumin and fetal calf serum on sperm quality, DNA fragmentation and lipid peroxidation of the liquid stored rabbit semen. Cryobiology 67: 1-6.
Sikka SC (1996) Oxidative stress and role of antioxidants in normal and abnormal sperm function. Front Biosci 1: 78-86.
Tan X, Yang Y, Xu J, Zhang P, Deng R, Mao Y, He J, Chen Y, Zhang Y, Ding J, Li H, Shen H, Li X, Dong W, Gang C (2020) Luteolin exerts neuroprotection via modulation of the p62/Keap1/Nrf2 pathway in intracerebral hemorrhage. Front Pharmacol 10: 1551.
Tvrdá E, Greifová H, Ďuračka M, Ondruška Ľ, Halenár M, Kolesárová A (2021) Comparative analysis of the detrimental in vitro effects of three fusariotoxins on the selected structural and functional characteristics of rabbit spermatozoa. Drug Chem Toxicol 45: 2519-2527.
Ugur MR, Abdelrahman AS, Evans HC, Gilmore AA. Hitit M, Arifiantini RL, Purwantara B, Kaya A, Memili E (2019) Advances in cryo-preservation of bull sperm. Front Vet Sci 6: 268.
Viudes-De-Castro MP, Mocé E, Lavara, R, Marco-Jiménez F, Vicente JS (2014) Aminopeptidase activity in seminal plasma and effect of dilution rate on rabbit reproductive performance after insemination with an extender supplemented with buserelin acetate. Theriogenology 81: 1223-1228.
Yahyazadeh A, Altunkaynak B (2019) Protective effects of luteolin on rat testis following exposure to 900 MHz electromagnetic field. Biotech Histochem 94: 298-307.
Yan Y, Jun C, Lu Y, Jiangmei S (2019) Combination of metformin and luteolin synergistically protects carbon tetrachloride‐induced hepato-toxicity: Mechanism involves antioxidant, anti‐inflammatory, antiapoptotic, and Nrf2/ /HO‐1 signaling pathway. Biofactors 45: 598-606.
Yu Q, Zhang M, Ying Q, Xie X, Yue S, Tong B, Wei Q, Bai Z, Ma L (2019) Decrease of AIM2 mediated by luteolin contributes to non-small cell lung cancer treatment. Cell Death Dis 10: 218.
Zhu Z, Fan X, Lv Y, Zhang N, Fan C, Zhang P, Zeng W (2015) Vitamin E analogue improves rabbit sperm quality during the process of cryopreservation through its antioxidative action. PloS One 10: e0145383.
Zhu Z, Li R, Lv Y, Zeng W (2019) Melatonin protects rabbit spermatozoa from cryo-damage via decreasing oxidative stress. Cryobiology 88: 1-8.