TY - JOUR N2 - An outstanding Polish biochemist, laureate of the Foundation for Polish Science Prize in 2007, member of the Polish Academy of Sciences, a head of the Department of Molecular Biomedicine at the Institute of Bioorganic Chemistry, PAS in Poznan Professor Wlodzimierz Krzyzosiak’s research path led from the structural chemistry of nucleic acids, through molecular genetics and cancer genetics to molecular medicine. In the last years, Professor's scientific activity focused on understanding the role of RNA in the pathogenesis of human neurological diseases caused by the expansion of repetitive sequences. He also developed new methods of experimental therapy for this group of disorders using antisense oligonucleotides and RNA interference technology. He analyzed the factors influencing the microRNA biogenesis and used this knowledge to improve RNA interference technology tools in therapeutic approaches. Overall, Professor Krzyżosiak coauthored more than 130 publications, which have been cited more than 3500 times so far. L1 - http://www.journals.pan.pl/Content/110463/PDF-MASTER/N118-08-Krzy%C5%BCosiak.pdf L2 - http://www.journals.pan.pl/Content/110463 PY - 2018 IS - No 1 EP - 166 KW - Włodzimierz Krzyżosiak KW - cancer genetics KW - trinucleotide repeats KW - polyglutamine diseases KW - RNA interference KW - microRNA A1 - Olejniczak, Marta A1 - Fiszer, Agnieszka PB - Biuro Upowszechniania i Promocji Nauki PAN DA - 2018.03.31 T1 - Professor Włodzimierz Krzyżosiak (28.01.1949 – 21.12.2017) SP - 161 UR - http://www.journals.pan.pl/dlibra/publication/edition/110463 T2 - Nauka ER -