TY - JOUR N2 - Gallbladder mucocele (GM) is a common extrahepatic biliary disease recognized in dogs and is defined as the expansion and extension of the gallbladder by an accumulation of semi-solid bile or bile acid. Histopathological diagnosis of necrotizing cholecystitis and transmural coagulative necrosis of the gallbladder wall shows poor prognosis. Conversely, histopathological diagnosis with partial necrotic findings is often achieved. We hypothesized that histopathological partial necrosis of the gallbladder wall is the primary lesion of necrotic cholecystitis or transmural ischemic necrosis. Therefore, we investigated the relationship between histopathological necrosis/ partial necrosis findings and their clinical conditions. We retrospectively analyzed 55 dogs diagnosed with GM that had undergone cholecystectomy at the Yamaguchi University Animal Medical Center. The group with histopathological necrosis/partial necrosis of the gallbladder wall showed elevated levels of preoperative white blood cells, alanine transaminase, alkaline phosphatase, γ-glutamyltransferase, total bilirubin, and C-reactive protein compared to the non-necrotic group. Partial necrosis of the gallbladder wall may affect the progression of the disease and hematological abnormalities. Additionally, all death cases until 2 weeks were included in the histopathological necrosis/partial necrosis group. In this study, we found that poor prognosis factors were associated with partial necrosis of the gallbladder wall. Furthermore, these cases of partial necrosis showed elevated levels of blood test parameters. These results suggest that necrosis of the gallbladder wall is associated with poor prognosis and poor pathophysiological conditions. L1 - http://www.journals.pan.pl/Content/123686/PDF/4%20_%20Itoh.pdf L2 - http://www.journals.pan.pl/Content/123686 PY - 2022 IS - No 2 EP - 229 DO - 10.24425/pjvs.2022.141806 KW - canine KW - cholecystectomy KW - gallbladder mucoceles KW - necrosis KW - gangrenous cholecystitis A1 - Itoh, H. A1 - Igari, K. A1 - Tani, K. A1 - Sunahara, H. A1 - Nemoto, Y. A1 - Nakaichi, M. A1 - Iseri, T. A1 - Horikirizono, H. A1 - Itamoto, K. PB - Polish Academy of Sciences Committee of Veterinary Sciences PB - University of Warmia and Mazury in Olsztyn VL - vol. 25 DA - 2022.07.10 T1 - Clinical relationship between histopathological necrotic/partial necrotic findings and disease condition of gallbladder mucoceles in dogs SP - 223 UR - http://www.journals.pan.pl/dlibra/publication/edition/123686 T2 - Polish Journal of Veterinary Sciences ER -