Details

Title

Immunoreactivity of acetylcholinesterase and M1 muscarinic receptors in the hippocampus and striatum of rats treated with Rebaudioside A

Journal title

Polish Journal of Veterinary Sciences

Yearbook

2022

Volume

vol. 25

Issue

No 2

Affiliation

Rycerz, K. : Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033, Lublin, Poland ; Jaworska-Adamu, J. : Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033, Lublin, Poland ; Krawczyk, A. : Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033, Lublin, Poland ; Arciszewski, M.B. : Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033, Lublin, Poland

Authors

Keywords

rebaudioside A ; stevia ; acetylcholinesterase ; hippocampus ; striatum ; rat

Divisions of PAS

Nauki Biologiczne i Rolnicze

Coverage

303-310

Publisher

Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn

Bibliography


Abdel-Aal RA, Abdel-Rahman MS, Al Bayoumi S, Ali LA (2021) Effect of stevia aqueous extract on the antidiabetic activity of saxagliptin in diabetic rats. J Ethnopharmacol 265: 113188.
Abudula R, Jeppesen PB, Rolfsen SE, Xiao J, Hermansen K (2004) Rebaudioside A potently stimulates insulin secretion from isolated mouse islets: studies on the dose-, glucose-, and calcium-dependency. Metabolism 53: 1378-1381.
Bazzari AH, Parri HR (2019) Neuromodulators and Long-Term Synaptic Plasticity in Learning and Memory: A Steered-Glutamatergic Per-spective. Brain Sci 9:300.
Betterton RT, Broad LM, Tsaneva-Atanasova K, Mellor JR (2017) Acetylcholine modulates gamma frequency oscillations in the hippocampus by activation of muscarinic M1 receptors. Eur J Neurosci 45: 1570-1585.
Casas-Grajales S, Ramos-Tovar E, Chávez-Estrada E, Alvarez-Suarez D, Hernández-Aquino E, Reyes -Gordillo K, Cerda-García-Rojas CM, Camacho J, Tsutsumi V, Lakshman MR, Muriel P (2019) Antioxidant and immunomodulatory activity induced by stevioside in liver damage: In vivo, in vitro and in silico assays. Life Sci 224: 187-196.
Chavushyan VA, Simonyan KV, Simonyan RM, Isoyan AS, Simonyan GM, Babakhanyan MA, Hovhannisyian LE, Nahapetyan KH, Avetisyan LG, Simonyan MA (2017) Effects of stevia on synaptic plasticity and NADPH oxidase level of CNS in conditions of metabolic disorders caused by fructose. BMC Complement Altern Med 17: 540.
Dyduch-Siemińska M, Najda A, Gawroński J, Balant S, Świca K, Żabaet A (2020) Stevia Rebaudiana Bertoni, a Source of High-Potency Natural Sweetener-Biochemical and Genetic Characterization. Molecules 25: 767.
El Falougy H, Kubikova E, Benuska J (2008) The microsco pical structure of the hippocampus in the rat. Bratisl Lek Listy 109: 106-110.
Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, Khachaturian AS, Vergallo A, Cavedo E, Snyder PJ, Kha-chaturian ZS (2018) The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease. Brain 141: 1917-1933.
Hazali N, Mohamed A, Ibrahim M, Masri M, Isa KA, Nor NM, Ayob MK, Fadzlan FN (2014) Effect of acute Stevia consumption on blood glucose response in healthy Malay young adults. Sains Malays 43: 649-654.
Ihara R, Vincent BD, Baxter MR, Franklin EE, Hassenstab JJ, Xiong C, Morris JC, Cairns NJ (2018) Relative neuron loss in hippocampal sclerosis of aging and Alzheimer’s disease. Ann Neurol 84: 741-753.
Jahanshahi M, Nickmahzar EG, Seif-hoseini S, Babakordi F, Moharreri A (2013) Scopolamine reduces the density of M1 muscarinic neurons in rats’ hippocampus. Int J Morphol 31: 1227-1232.
Janeczek M, Gefen T, Samimi M, Kim G, Weintraub S, Bigio E, Rogalski E, Mesulam M, Geula C (2018) Variations in Acetylcholinesterase Activity within Human Cortical Pyramidal Neurons Across Age and Cognitive Trajectories. Cereb Cortex 28: 1329-1337.
Juyal DS, Arun K, Ganga B (2010a) Effect of Stevia rebau diana (Bert.) extract on memory and acetylcholinesterase activity in young and aged rats. J Glob Pharma Technol 2: 62-68.
Juyal DS, Bisht G, Kumar A (2010b) Memory enhancing effect of ethanolic extract of Stevia rebaudiana (Bert.). Int J Phytomed 2: 166-171.
Konar A, Gupta R, Shukla RK, Maloney B, Khanna VK, Wadhwa R, Lahiri DK, Thakur MK (2019) M1 musca rinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera. Sci Rep 9: 13990.
Krawczyk MC, Millan J, Blake MG, Boccia MM (2021) Critical role of hippocampal muscarinic acetylcholine receptors on memory recon-solidation in mice. Neurobiol Learn Mem 177: 107360.
Mann T, Zilles K, Klawitter F, Cremer M, Hawlitschka A, Palomero-Gallagher N, Schmidt O, Wree A (2018) Acetylcholine Neurotransmitter Receptor Densities in the Striatum of Hemiparkinsonian Rats Following Botulinum Neurotoxin-A Injection. Front Neuroanat 12: 65.
Momtazi-Borojeni AA, Esmaeili SA, Abdollahi E, Sahebkar A (2017) A Review on the Pharmacology and Toxicology of Steviol Glycosides Extracted from Stevia rebaudiana. Curr Pharm Des 23: 1616-1622.
Nguyen DH, Zhou T, Shu J, Mao J (2013) Quantifying chromogen intensity in immunohistochemistry via reciprocal intensity. Cancer In-Cytes 2: 1-4.
Ni R, Huang Z, Shu Y, Wang Y, Li T, Zhou J (2018) Atlas of the Striatum and Globus Pallidus in the Tree Shrew: Comparison with Rat and Mouse. Neurosci Bull 34: 405-418.
Nunes AP, Ferreira-Machado SC, Nunes RM, Dantas FJ, De Mattos JC, Caldeira-de-Araujo A (2007) Analysis of genotoxic potentiality of stevioside by comet assay. Food Chem Toxicol 45: 662-666.
Pasqualli T, Chaves PE, Pereira CL, Serpa EA, Oliviera LF, Machado MM (2020) Steviol, the active principle of the stevia sweetener, causes a reduction of the cells of the immunological system even consumed in low concentrations. Immunopharmacol Immunotoxicol 42: 504-508.
Picciotto MR, Higley MJ, Mineur YS (2012) Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. Neuron 76: 116-129.
Radu BM, Osculati AM, Suku E, Banciu A, Tsenov G, Merigo F, Di Chio M, Banciu DD, Tognoli C, Kacer P, Giorgetti A, Radu M, Bertini G, Fabene PF (2017) All muscarinic acetylcholine receptors (M1-M5) are expressed in murine brain microvascular endothelium. Sci Rep 7: 5083.
Scarpa M, Hesse S, Bradley SJ (2020) M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer’s disease? Adv Pharmacol 88: 277-310.
Sharma D, Puri M, Tiwary AK, Singh N, Jaggi AS (2010) Antiamnesic effect of stevioside in scopolamine-treated rats. Indian J Pharmacol 42: 164-167.
Tao R, Cho S (2020) Consumer-based sensory characterization of steviol glycosides (Rebaudioside A, D, and M). Foods 9: 1026.
Veurink G, Perry G, Singh SK (2021) Role of antioxidants and a nutrient rich diet in Alzheimer’s disease. Open Biol 10: 200084.
Yi JH, Whitcomb DJ, Park SJ, Martinez-Perez C, Barbati SA, Mitchell SJ, Cho K (2020) M1 muscarinic acetylcholine receptor dysfunction in moderate Alzheimer’s disease pathology. Brain Commun 2: fcaa058.

Date

2022.07.10

Type

Article

Identifier

DOI: 10.24425/pjvs.2022.141815
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