Details

Title

Investigation of A2 allele frequency in Taiwanese Holstein cattle using genetictes ting

Journal title

Polish Journal of Veterinary Sciences

Yearbook

2025

Volume

vol. 28

Issue

No 2

Authors

Affiliation

Chao, C.H. : Northern Region Branch, Taiwan Livestock Research Institute, Ministry of Agriculture, 207-5, Bi-tou-mian, Wu-hoo village, Si-hoo Township, Miaoli County, Taiwan ; Shiau, J.W. : Northern Region Branch, Taiwan Livestock Research Institute, Ministry of Agriculture, 207-5, Bi-tou-mian, Wu-hoo village, Si-hoo Township, Miaoli County, Taiwan

Keywords

Holstein cattle ; genetic testing ; A2 β-casein

Divisions of PAS

Nauki Biologiczne i Rolnicze

Coverage

303-309

Publisher

Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn

Bibliography

Ardicli S, Aldevir O, Aksu E, Gumen A (2023) The variation in the beta-casein genotypes and its effect on milk yield and genomic values in Holstein-Friesian cows. Anim Biotechnol 34: 4116-4125.

Ariton A, Neculai-Valeanu AS, Poroșnicu I (2023) Impact of A2 milk on human health and the dairy industry – a review. Sci Pap J Vet Ser 66: 96-99.

Bors A, Bors SI, Floriștean VC (2024) Health-related outcomes and molecular methods for the characterization of A1 and A2 cow’s milk: review and update. Vet Sci 11: 172.

Caroli AM, Chessa S, Erhardt GJ (2009) Invited review: milk protein polymorphisms in cattle: effect on animal breeding and human nutrition. J Dairy Sci 92: 5335-5352.

Cattaneo S, Masotti F, Stuknyte M, De Noni I (2023) Impact of in vitro static digestion method on the release of beta-casomorphin-7 from bovine milk and cheeses with A1 or A2 beta-casein phenotypes. Food Chem 404: 134617.

Chao CH, Yeh YH, Chen YM, Lee KH, Wang SH, Lin TY (2022) Sire pedigree error estimation and sire verification of the Taiwan dairy cattle population by using SNP markers. Pol J Vet Sci 25: 61-65.

Choi Y, Kim N, Song CH, Kim S, Lee DH (2024) The effect of A2 milk on gastrointestinal symptoms in comparison to A1/A2 milk: a single-center, randomized, double-blind, cross-over study. J Cancer Prev 29: 45-53.

Dantas A, Kumar H, Prudencio ES, de Avila LB Junior, Orellana-Palma P, Dosoky NS, Nepovimova E, Kuca K, Cruz-Martins N, Verma R (2023) An approach on detection, quantification, technological properties, and trends market of A2 cow milk. Food Res Int 167: 112690.

European Food Safety Authority (2009) Review of the potential health impact of β-casomorphins and related peptides. EFSA J 7: 231.

Faggion S, Degano L, Carnier P, Bonfatti V (2025) β-casein A2 affects milk renneting properties, cheese yield before and after ripening, and alters the texture of Caciotta cheese produced in field conditions. J Dairy Sci 108: 3199-3213.

Fernández-Rico S, Mondragón ADC, López-Santamarina A, Cardelle-Cobas A, Regal P, Lamas A, Ibarra IS, Cepeda A, Miranda JM (2022) A2 milk: new perspectives for food technology and human health. Foods 11: 2387.

He M, Sun J, Jiang ZQ, Yang YX (2017) Effects of cow’s milk beta-casein variants on symptoms of milk intolerance in Chinese adults: a multicentre, randomised controlled study. Nutr J 16: 72.

Ho S, Woodford K, Kukuljan S, Pal S (2014) Comparative effects of A1 versus A2 beta-casein on gastrointestinal measures: a blinded randomized cross-over pilot study. Eur J Clin Nutr 68: 994-1000.

Hohmann LG, Yin T, Schweizer H, Giambra IJ, König S, Scholz AM (2021) Comparative effects of milk containing A1 versus A2 β-casein on health, growth and β-casomorphin-7 level in plasma of neonatal dairy calves. Animals (Basel) 11: 55.

Illumina (2017) Infinium XT Assay. Document # 1000000016440v01. https://support.illumina.com/content/dam/illumina-support/documents/documentation//chemistry
_documentation/infinium_assays/infinium-xt/infinium-xtht-reference-guide-1000000016440-01.pdf

Jeong H, Park YS, Yoon SS (2024) A2 milk consumption and its health benefits: an update. Food Sci Biotechnol 33: 491-503.

Jiménez-Montenegro L, Alfonso L, Mendizabal JA, Urrutia O (2022) Worldwide research trends on milk containing only A2 β-casein: a bibliometric study. Animals (Basel) 12: 1909.

Kamiński S, Cieślińska A, Kostyra E (2007) Polymorphism of bovine beta-casein and its potential effect on human health. J Appl Genet 48: 189-198.

Kappes R, Schneider V, Schweizer H, Nüske S, Knob DA, Thaler Neto A, Scholz AM (2024) Effect of β-casein A1 or A2 milk on body composition, milk intake, and growth in Holstein, Simmental, and crossbred dairy calves of both sexes. J Dairy Sci 107: 4033-4044.

Miluchová M, Gábor M, Candrák J (2023) The effect of the genotypes of the CSN2 gene on test-day milk yields in the Slovak Holstein cow. Agriculture 13: 154.

Park YW, Haenlein GFW (2021) A2 bovine milk and caprine milk as a means of remedy for milk protein allergy. Dairy 2: 191-201.

Ramakrishnan M, Eaton TK, Sermet OM, Savaiano DA (2020) Milk containing A2 β-casein only, as a single meal, causes fewer symptoms of lactose intolerance than milk containing A1 and A2 β-caseins in subjects with lactose maldigestion and intolerance: a randomized, double-blind, crossover trial. Nutrients 12: 3855.

Ramakrishnan M, Mysore Saiprasad S, Savaiano DA (2024) Prolonged consumption of A2 β-casein milk reduces symptoms compared to A1 and A2 β-casein milk in lactose maldigesters: a two-week adaptation study. Nutrients 16: 1963.

Sebastiani C, Arcangeli C, Ciullo M, Torricelli M, Cinti G, Fisichella S, Biagetti M. (2020) Frequencies evaluation of β-casein gene polymorphisms in dairy cows reared in central Italy. Animals (Basel) 10: 252.

Sheng X, Li Z, Ni J, Yelland G (2019) Effects of conventional milk versus milk containing only A2 β-casein on digestion in Chinese children: a randomized study. J Pediatr Gastroenterol Nutr 69: 375-382.

Smolenski G, Armstrong K, Trivedi M, Clarke A (2025) BCM-7 release from processed dairy products containing measured amounts of beta-casein variants. Int Dairy J 161: 106136.

Summer A, Di Frangia F, Ajmone Marsan P, De Noni I, Malacarne M (2020) Occurrence, biological properties and potential effects on human health of beta-casomorphin 7: Current knowledge and concerns. Crit Rev Food Sci Nutr 60: 3705-3723.

Ul Haq MR, Kapila R, Kapila S (2015) Release of β-casomorphin-7/5 during simulated gastrointestinal digestion of milk β-casein variants from Indian crossbred cattle (Karan Fries). Food Chem 168: 70-79.

Yamada A, Sugimura M, Kuramoto T (2021) Genetic polymorphism of bovine beta-casein gene in Japanese dairy farm herds. Anim Sci J 92: e13644.

Żbik K, Onopiuk A, Górska-Horczyczak E, Wierzbicka A (2024) Trends and opportunities in the dairy industry: A2 milk and processing methods. Appl Sci 14: 6513.

 

Date

13.06.2025

Type

Article

Identifier

DOI: 10.24425/pjvs.2025.154951
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