This article addresses the issue of the role of regions, big cities and urban areas in the socio-economic and spatial development trends in the EU as well Poland shaped through – and in connection with the process of globalization and functioning of the Common Market. The analysis of the situation and trends is prepared on the basis of the recent reports and data presented by the EC and OECD and – in case of Poland – Ministry of Investment and Economic Development as well Main Statistical Offi ce. Against this background with the reference to other research work published recently and his own experience the Author formulates a number of proposals for modification of territorially sensitive socio-economic policy in Poland (at national, regional as well urban level).