The article presents the biometeorological impact of thermal and humidity conditions on the human body in the Hornsund area in the southern Spitsbergen, Svalbard. This was determined based on diurnal air temperature range, the day-to-day variation in average diurnal air temperature and the average diurnal relative humidity. The temporal variability of thermal and humidity biometeorological stimuli in Hornsund was examined for the period 01.11.1978–31.12.2017. A lessening of biometeorological impact was found in the southern Spitsbergen region, including a statistically significant negative trend in strongly- and severely-felt stimuli (according to diurnal air temperature range), and in significant and severe stimuli (according to day-to-day variation in average diurnal air temperature). A non-significant positive trend was observed in the number of days of relative humidity with humid and very humid air. To analyse the spatial variability of the stimuli around the Hornsund fjord, data were used from seven year-round measuring stations for the period 01.07.2014–31.06.2015. The most unfavourable conditions were found on the Hans Glacier, on the summit of Fugleberget and inside the fjord. The paper presents the role of atmospheric circulation on thermal and humidity stimuli. In the Hornsund region, the highest probability of unfavourable sensible temperatures for humans occurring during the year was mostly in winter and early spring. This was related to the advection of air masses from the north-east sector, regardless of baric regime type. It was found that very humid air (> 85%) flowed over Hornsund for practically the entire year from the S–SW as part of both cyclonic and anti-cyclonic systems.